HANK & LIN'S GROUP
The past is prologue and the future is scintillating
I.芳香化酶探针（imaging agent for aromatase）：
芳香化酶是催化雌激素生物合成的限时酶，参与许多生理过程和疾病。这种酶广泛分布于许多器官，包括性腺组织、胃和大脑。基于芳香化酶抑制剂的显像剂将是研究其在大脑和外周组织中的功能的有用工具。
1.Jin Song, Zehui Wu, Seok Choi, Karl Ploessl and Hank Kung.A potential imaging agent for aromatase: 4-[[(4-iodophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]-benzonitrile.Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1334
2.Jin Song, Zehui Wu, Beau Wangtrakuldee, Seok Rye Choi, Zhihao Zha, Karl Ploessl, Robert H. Mach, and Hank Kung. "4-(((4-Iodophenyl) methyl)-4 H-1, 2, 4-triazol-4-ylamino)-benzonitrile: A Potential Imaging Agent for Aromatase." Journal of Medicinal Chemistry 59, no. 20 (2016): 9370-9380.
II. 乏氧显像探针（imaging agent for hypoxia）：
1.Zhang, Lifang, Xinyue Yao, Jianhua Cao, Haiyan Hong, Aili Zhang, Ruiyue Zhao, Yan Zhang et al. "In vivo ester hydrolysis as a new approach in development of positron emission tomography tracers for imaging hypoxia." Molecular Pharmaceutics 16, no. 3 (2019): 1156-1166.
2.Zha, Zhihao, Lin Zhu, Yajing Liu, Fenghua Du, Hongmei Gan, Jinping Qiao, and Hank F. Kung. "Synthesis and evaluation of two novel 2-nitroimidazole derivatives as potential PET radioligands for tumor imaging." Nuclear medicine and biology 38, no. 4 (2011): 501-508.
3.Cao, Jianhua, Yajing Liu, Lifang Zhang, Fenghua Du, Yingqian Ci, Yan Zhang, Hao Xiao et al. "Synthesis of novel PEG-modified nitroimidazole derivatives via “hot-click” reaction and their biological evaluation as potential PET imaging agent for tumors." Journal of Radioanalytical and Nuclear Chemistry 312, no. 2 (2017): 263-276.
