HANK & LIN'S GROUP
The past is prologue and the future is scintillating
2005-2009
2009
1. Chacko, Ann-Marie, Eric Blankemeyer, Brian P. Lieberman, Wenchao Qu, and Hank F. Kung. "5-[18F] Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression." Nuclear medicine and biology 36, no. 1 (2009): 29-38.
2. Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF. Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med. 2009 Nov;50(11):1887-94. doi: 10.2967/jnumed.109.065284. Epub 2009 Oct 16. PMID: 19837759; PMCID: PMC3065020.
3. Qiao H, Zhang H, Zheng Y, Ponde DE, Shen D, Gao F, Bakken AB, Schmitz A, Kung HF, Ferrari VA, Zhou R. Embryonic stem cell grafting in normal and infarcted myocardium: serial assessment with MR imaging and PET dual detection. Radiology. 2009 Mar;250(3):821-9. doi: 10.1148/radiol.2503080205. PMID: 19244049; PMCID: PMC2680165.
4. Qiao, Hui, Suleman Surti, Seok Rye Choi, Karthik Raju, Hualei Zhang, Datta E. Ponde, Hank F. Kung, Joel Karp, and Rong Zhou. "Death and proliferation time course of stem cells transplanted in the myocardium." Molecular Imaging and Biology 11, no. 6 (2009): 408-414.
5. Qu W, Ploessl K, Truong H, Kung MP, Kung HF. Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3382-5. doi: 10.1016/j.bmcl.2009.05.035. Epub 2009 May 18. PMID: 19467599.
6. Scott PJ, Hockley BG, Kung HF, Manchanda R, Zhang W, Kilbourn MR. Studies into radiolytic decomposition of fluorine-18 labeled radiopharmaceuticals for positron emission tomography. Appl Radiat Isot. 2009 Jan;67(1):88-94. doi: 10.1016/j.apradiso.2008.08.015. Epub 2008 Sep 7. PMID: 18951032; PMCID: PMC5938091.
7. Serdons K, Van Laere K, Janssen P, Kung HF, Bormans G, Verbruggen A. Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents. J Med Chem. 2009 Nov 26;52(22):7090-102. doi: 10.1021/jm900871v. PMID: 19877643.
8. Serdons, K., D. Vanderghinste, M. Van Eeckhoudt, P. Borghgraef, H. Kung, F. Van Leuven, T. De Groot, G. Bormans, and A. Verbruggen. "Synthesis and evaluation of two fluorine‐18 labelled phenylbenzothiazoles as potential in vivo tracers for amyloid plaque imaging." Journal of Labelled Compounds and Radiopharmaceuticals: The Official Journal of the International Isotope Society 52, no. 11 (2009): 473-481.
9. Serdons, Kim, Tom Verduyckt, Dominique Vanderghinste, Peter Borghgraef, Jan Cleynhens, Freddy Van Leuven, Hank Kung, Guy Bormans, and Alfons Verbruggen. "11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer's disease." European journal of medicinal chemistry 44, no. 4 (2009): 1415-1426.
10. Serdons, Kim, Tom Verduyckt, Dominique Vanderghinste, Jan Cleynhens, Peter Borghgraef, Peter Vermaelen, Christelle Terwinghe et al. "Synthesis of 18F-labelled 2-(4′-fluorophenyl)-1, 3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C] PIB." Bioorganic & medicinal chemistry letters 19, no. 3 (2009): 602-605.
11. Serdons, Kim, Christelle Terwinghe, Peter Vermaelen, Koen Van Laere, Hank Kung, Luc Mortelmans, Guy Bormans, and Alfons Verbruggen. "Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer’s disease." Journal of medicinal chemistry 52, no. 5 (2009): 1428-1437.
12. Wang JL, Parhi AK, Oya S, Lieberman B, Kung HF. In vivo characterization of a series of 18F-diaryl sulfides (18F-2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)phenylthio)benzenamine) for PET imaging of the serotonin transporter. J Nucl Med. 2009 Sep;50(9):1509-17. doi: 10.2967/jnumed.108.060723. Epub 2009 Aug 18. PMID: 19690040.
13. Wey SP, Weng CC, Lin KJ, Yao CH, Yen TC, Kung HF, Skovronsky D, Kung MP. Validation of an (18)F-labeled biphenylalkyne as a positron emission tomography imaging agent for beta-amyloid plaques. Nucl Med Biol. 2009 May;36(4):411-7. doi: 10.1016/j.nucmedbio.2009.01.013. Epub 2009 Mar 26. PMID: 19423009.
14. Zhu L, Liu J, Kung HF. Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5026-8. doi: 10.1016/j.bmcl.2009.07.048. Epub 2009 Jul 24. PMID: 19632829.
15. Chandra, Rajesh, Shunichi Oya, Brian Lieberman, Seok-Rye Choi, and Hank F. Kung. "Synthesis and biological evaluation of FPEG-6-heteroaryl-quinoline derivatives as potential tau imaging agents." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 238. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2009.
16. Choi, Seok Rye, Brian Lieberman, Franz Hefti, Daniel Skovronsky, and H. Kung. "F-18 AV-133 as a biomarker for pancreas beta islet cells." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 321.
17. Choi, Seok Rye, Daniel Skovronsky, Franz Hefti, Nicolette Honson, Jeff Kuret, and H. Kung. "Florpiramine F 18 (AV-45) is an amyloid plaque-selective PET imaging agent." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1202.
18. Choi, Seok Rye, Daniel Skovronsky, Franz Hefti, A. Carpenter, Geoffrey Golding, Zhi-Ping Zhuang, Nathaniel Lim, Tyler Benedum, Wei Zhang, and H. Kung. "F-18 AV-45 (florpiramine F-18): a PET imaging agent for mapping beta-amyloid plaques in the brain." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1190.
19. Han, Jun, Erwen Mei, Mei-Ping Kung, Hank F. Kung, Jian-Min Yuan, and Hai-Lung Dai. "Initial dimer formation and polymerization of the beta-amyloid (1-40) peptides studied by time-resolved fluorescence resonance energy transfer." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 238. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2009.
20. Ichise, M., Mark Slifstein, Balu Easwaramoorthy, S. A. Bae, A. Carpenter, A. Maffei, Ronald Van Heertum, H. Kung, and P. Harris. "VMAT2 imaging of baboons with two 18F-FP-DTBZ enantiomers." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1206.
21. Kung, Hank F., Lin Zhu, Karl Ploessl, Wenchao Qu, Zhihao Zha, and Brian P. Lieberman. "Synthesis of 4-[F-18] fluoro-L-glutamine: A new PET tracer for tumor imaging." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 238. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2009.
22. Oya, Shunichi, Wenchao Qu, Datta Ponde, Brian Lieberman, Rajesh Kamble, Roland Knoblauch, David Wise, Craig Thompson, and H. Kung. "Preparation of [11C] glutamine as a metabolic tracer for imaging glutaminolysis in tumor cells." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 264.
23. Qu, Wenchao, Zhihao Zha, and Hank F. Kung. "Facile synthesis of 4-hydroxy and 4-fluoro-L-glutamine derivatives using Passerini reaction as a key assembly step." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 238. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2009.
24. Qu, Wenchao, Zhihao Zha, and Hank F. Kung. "Facile synthesis of carbon-13 and deuterium labeled L-glutamine." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 238. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2009.
25. Qu, Wenchao, Karl Ploessl, Hong Truong, Mei-Ping Kung, and H. Kung. "Synthesis of novel 4-iodophenyl sphingosine derivatives as potential tumor imaging agents." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 440;
26. Rowe, C. C., R. S. Mulligan, S. Pejoska, V. L. Villemagne, R. K. Dhamija, J. Drago, D. Skovronsky, and H. F. Kung. "Quantification of striatal vesicular monoamine transporters in the human brain with [18F] AV133." (2009).
27. Rowe, Christopher, Rajinder Dhamija, John Drago, Rachel Mulligan, Svetlana Pejoska, Andrew Hughes, Graeme O'Keefe, Daniel Skovronsky, Hank Kung, and Victor Villemagne. "In vivo quantification of striatal VMAT2 with [F-18] AV133." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 124.
28. Serdons, Kim, Koen Van Laere, Peter Janssen, Hank Kung, Guy Bormans, and Alfons Verbruggen. "Three new 18f-labelled phenylbenzothiazoles as potential amyloid imaging agents." Journal of labelled compounds & radiopharmaceuticals 52 (2009): S88-S88.
29. Wang, Julie, Shunichi Oya, Brian Lieberman, and H. Kung. "PET imaging of serotonin transporters in the brain of unilateral 6-hydroxydopamine lesioned rats." Journal of Nuclear Medicine May 2009, 50 (supplement 2) 485.
30. Zhu, Lin, Jingying Liu, and Hank F. Kung. "Synthesis and evaluation of 2-amino-dihydroxytetrabenazine derivatives as probes for the vesicular monoamine transporter-2." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 238. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2009.
2008
1. Chacko AM, Qu W, Kung HF. Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling. J Org Chem. 2008 Jul 4;73(13):4874-81. doi: 10.1021/jo800444y. Epub 2008 Jun 4. PMID: 18522415; PMCID: PMC4122541.
2. Chacko AM, Qu W, Kung HF. Synthesis and in vitro evaluation of 5-[(18)f]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression. J Med Chem. 2008 Sep 25;51(18):5690-701. doi: 10.1021/jm800501d. PMID: 18800764; PMCID: PMC4122542.
3. Kung HF, Lieberman BP, Zhuang ZP, Oya S, Kung MP, Choi SR, Poessl K, Blankemeyer E, Hou C, Skovronsky D, Kilbourn M. In vivo imaging of vesicular monoamine transporter 2 in pancreas using an (18)F epoxide derivative of tetrabenazine. Nucl Med Biol. 2008 Nov;35(8):825-37. doi: 10.1016/j.nucmedbio.2008.08.004. PMID: 19026944; PMCID: PMC2632775.
4. Kung MP, Hou C, Lieberman BP, Oya S, Ponde DE, Blankemeyer E, Skovronsky D, Kilbourn MR, Kung HF. In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus. J Nucl Med. 2008 Jul;49(7):1171-6. doi: 10.2967/jnumed.108.051680. Epub 2008 Jun 13. PMID: 18552132.
5. Lakshmi B, Kung MP, Lieberman B, Zhao J, Waterhouse R, Kung HF. (R)-N-Methyl-3-(3-(125)I-pyridin-2-yloxy)-3-phenylpropan-1-amine: a novel probe for norepinephrine transporters. Nucl Med Biol. 2008 Jan;35(1):43-52. doi: 10.1016/j.nucmedbio.2007.08.007. Epub 2007 Nov 19. PMID: 18158942; PMCID: PMC2277507.
6. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan;104(2):457-68. doi: 10.1111/j.1471-4159.2007.04972.x. Epub 2007 Oct 22. PMID: 17953662.
7. Parhi AK, Kung MP, Ploessl K, Kung HF. Synthesis of Fluorescent Probes based on Stilbenes and Diphenylacetylenes targeting β-Amyloid Plaques. Tetrahedron Lett. 2008;49(12):3395-3399. doi: 10.1016/j.tetlet.2008.03.130. PMID: 19122762; PMCID: PMC2504756.
8. Plössl K, Chandra R, Qu W, Lieberman BP, Kung MP, Zhou R, Huang B, Kung HF. A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent. Nucl Med Biol. 2008 Jan;35(1):83-90. doi: 10.1016/j.nucmedbio.2007.08.002. Epub 2007 Nov 19. PMID: 18158947; PMCID: PMC2837279.
9. Qu W, Choi SR, Hou C, Zhuang Z, Oya S, Zhang W, Kung MP, Manchandra R, Skovronsky DM, Kung HF. Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for beta-amyloid plaques. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4823-7. doi: 10.1016/j.bmcl.2008.07.077. Epub 2008 Jul 24. PMID: 18707879; PMCID: PMC2577917.
10. Stephenson KA, Reid LC, Zubieta J, Babich JW, Kung MP, Kung HF, Valliant JF. Synthesis and screening of a library of Re/Tc-based amyloid probes derived from beta-breaker peptides. Bioconjug Chem. 2008 May;19(5):1087-94. doi: 10.1021/bc800001g. Epub 2008 Apr 12. PMID: 18407681.
11. Song PJ, Bernard S, Sarradin P, Vergote J, Barc C, Chalon S, Kung MP, Kung HF, Guilloteau D. IMPY, a potential beta-amyloid imaging probe for detection of prion deposits in scrapie-infected mice. Nucl Med Biol. 2008 Feb;35(2):197-201. doi: 10.1016/j.nucmedbio.2007.10.005. Epub 2007 Dec 20. PMID: 18312829.
12. Wang JL, Parhi AK, Oya S, Lieberman B, Kung MP, Kung HF. 2-(2'-((Dimethylamino)methyl)-4'-(3-[(18)F]fluoropropoxy)-phenylthio)benzenamine for positron emission tomography imaging of serotonin transporters. Nucl Med Biol. 2008 May;35(4):447-58. doi: 10.1016/j.nucmedbio.2008.02.009. PMID: 18482682; PMCID: PMC2474748.
13. Chacko, Ann-Marie, Wenchao Qu, and Hank Kung. "Novel C-5 [18F] fluoroalkylated nucleosides for PET imaging of HSV1-tk gene expression." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 12P.
14. Ichise, Masanori, Sara Plett, Abhinay Joshi, Yaakov Stern, Ronald Van Heertum, Val Lowe, Edward Coleman, Mark Mintun, Dean Wong, and Hank Kung. "Quantitative comparison of three novel 18F-labeled ligands for PET imaging of brain amyloid-β plaques in Alzheimer's disease." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 214P.
15. Lieberman, Brian, Zhi-Ping Zhuang, Catherine Hou, Mei-Ping Kung, Shunichi Oya, Eric Blankemeyer, Daniel Skovronsky, Rajesh Manchanda, Michael Kilbourn, and Hank Kung. "F-18 (+)-Epoxide FP-DTBZ: A new PET ligand for measuring beta cell mass in the pancreas." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 142P.
16. Plett, Sara, David Leung, Agata Jurewicz, Michael Farwell, Mark Slifstein, Rajesh Manchanda, Daniel Skovronsky, Ronald Van Heertum, Hank Kung, and Masanori Ichise. "Quantification of vesicular monoamine transporters in the primate brain with [18F] 9-fluoropropyl-(+)-DTBZ." (2008): Journal of Nuclear Medicine May 2008, 49 (supplement 1) 80P.
17. Qu, Wenchao, Mei-Ping Kung, Seok-Rye Choi, Catherine Hou, Zhiping Zhuang, Shunichi Oya, Wei Zhang, Rajesh Manchandra, Daniel Skovronsky, and Hank Kung. "Novel indolinyl-and indolyl-phenylacetylenes as potential PET imaging agents for probing β-amyloid plaques." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 287P.
18. Rowe, Christopher, Uwe Ackermann, Rachel Mulligan, Graeme O'Keefe, Hank Kung, Daniel Skovronsky, Thomas Dyrks, Ludger Dinkelborg, Colin Masters, and Victor Villemagne. "Beta-amyloid imaging with 18F-BAY94-9172 (AV1/ZK) PET in the differential diagnosis of Alzheimer’s disease from fronto-temporal lobar degeneration." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 35P.
19. Rowe, Christopher C., Uwe Ackermann, Rachel S. Mulligan, Tim Saunder, Graeme O'Keefe, Hank F. Kung, Daniel Skovronsky et al. "IC‐P3‐208: In vivo characterization of 18F‐BAY94–9172: A novel β‐amyloid PET ligand for the diagnosis of Alzheimer's disease." Alzheimer's & Dementia 4 (2008): T89-T89.
20. Skovronsky, Daniel, R. Edward Coleman, Kirk Frey, Pradeep Garg, Masanori Ichise, Val Lowe, Mark Mintun, Dean Wong, and Hank Kung. "Results of multi-center clinical trials comparing four 18F PET amyloid-imaging agents: preclinical to clinical correlations." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 34P.
21. Wang, Julie, Eric Deutsch, Shunichi Oya, and Hank Kung. "[125I] Flip-ADAM (2-(((2’-((dimethylamino) methyl)-4’-iodo) phenyl) thio) phenylamine): A potential new SPECT imaging agent for serotonin transporters." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 4P.
22. Wang, Julie, Ajit Parhi, Shunichi Oya, Brian Lieberman, and Hank Kung. "Structure activity relationships of a series of F-18 labeled 2-(2′-((Dimethylamino) methyl)-4′-(3-[18F] fluoroalkoxy)-phenylthio) benzenamine derivatives for PET imaging of the serotonin transporter." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 206P.
23. Weng, C., S. Wey, C. Yao, T. Yen, H. F. Kung, D. Skovronsky, and M. Kung. "Validation of a novel F-18-labeled biphenylalkyne as a PET imaging agent for beta-amyloid plaques." In EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 35, pp. S131-S131. 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER, 2008.
24. Zhang, Wei, Mei-Ping Kung, Catherine Hou, Shunichi Oya, Daniel Skovronsky, Rajesh Manchanda, Seok-Rye Choi, and Hank Kung. "Phenapth and napthphen derivatives as PET imaging agents for Alzheimer’s disease." Journal of Nuclear Medicine May 2008, 49 (supplement 1) 143P.
2007
1. Chandra R, Oya S, Kung MP, Hou C, Jin LW, Kung HF. New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques. J Med Chem. 2007 May 17;50(10):2415-23. doi: 10.1021/jm070090j. Epub 2007 Apr 21. PMID: 17447752.
2. Kilbourn MR, Hockley B, Lee L, Hou C, Goswami R, Ponde DE, Kung MP, Kung HF. Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain. Nucl Med Biol. 2007 Apr;34(3):233-7. doi: 10.1016/j.nucmedbio.2007.01.007. PMID: 17383572; PMCID: PMC1905841.
3. Kung HF, Kung MP, Wey SP, Lin KJ, Yen TC. Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT. Nucl Med Biol. 2007 Oct;34(7):787-9. doi: 10.1016/j.nucmedbio.2007.03.010. Epub 2007 May 11. PMID: 17921030.
4. Kung MP, Hou C, Goswami R, Ponde DE, Kilbourn MR, Kung HF. Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters. Nucl Med Biol. 2007 Apr;34(3):239-46. doi: 10.1016/j.nucmedbio.2006.12.005. PMID: 17383573; PMCID: PMC1919419.
5. Oya S, Choi SR, Kung MP, Kung HF. 5-Chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine: a new serotonin transporter ligand. Nucl Med Biol. 2007 Feb;34(2):129-39. doi: 10.1016/j.nucmedbio.2006.12.002. PMID: 17307121; PMCID: PMC1892637.
6. Parhi AK, Wang JL, Oya S, Choi SR, Kung MP, Kung HF. 2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents. J Med Chem. 2007 Dec 27;50(26):6673-84. doi: 10.1021/jm070685e. Epub 2007 Dec 4. PMID: 18052090; PMCID: PMC2532952.
7. Qu W, Kung MP, Hou C, Jin LW, Kung HF. Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3581-4. doi: 10.1016/j.bmcl.2007.04.062. Epub 2007 Apr 25. PMID: 17502139; PMCID: PMC1950143.
8. Qu W, Kung MP, Hou C, Oya S, Kung HF. Quick assembly of 1,4-diphenyltriazoles as probes targeting beta-amyloid aggregates in Alzheimer's disease. J Med Chem. 2007 Jul 12;50(14):3380-7. doi: 10.1021/jm070467l. Epub 2007 Jun 15. PMID: 17569520; PMCID: PMC3374157.
9. Qu W, Kung MP, Hou C, Benedum TE, Kung HF. Novel styrylpyridines as probes for SPECT imaging of amyloid plaques. J Med Chem. 2007 May 3;50(9):2157-65. doi: 10.1021/jm070025+. Epub 2007 Apr 6. PMID: 17411026.
10. Stephenson KA, Chandra R, Zhuang ZP, Hou C, Oya S, Kung MP, Kung HF. Fluoro-pegylated (FPEG) imaging agents targeting Abeta aggregates. Bioconjug Chem. 2007 Jan-Feb;18(1):238-46. doi: 10.1021/bc060239q. PMID: 17226978; PMCID: PMC2597429.
11. Zeng, Chenbo, Suwanna Vangveravong, Jinbin Xu, Katherine C. Chang, Richard S. Hotchkiss, Kenneth T. Wheeler, Duanwen Shen, Zhi-Ping Zhuang, Hank F. Kung, and Robert H. Mach. "Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy." Cancer research 67, no. 14 (2007): 6708-6716.
12. Zhang W, Kung MP, Oya S, Hou C, Kung HF. 18F-labeled styrylpyridines as PET agents for amyloid plaque imaging. Nucl Med Biol. 2007 Jan;34(1):89-97. doi: 10.1016/j.nucmedbio.2006.10.003. Epub 2006 Dec 12. PMID: 17210465.
13. Chandra, Rajesh, Shunichi Oya, Mei-Ping Kung, Catherine Hou, and Hank Kung. "18F-Pegylated alkynes as potential PET imaging agents for Alzheimer’s disease." Journal of Nuclear Medicine May 2007, 48 (supplement 2) 301P.
14. Han, Jun, Erwen Mei, Mei-Ping Kung, Hank F. Kung, and Hai-Lung Dai. "Beta-amyloid peptide dimer formation and structure by fluorescence resonance energy transfer and correlation microscopy." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 233. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2007.
15. Kung, H., M. P. Kung, B. Lieberman, C. Hou, D. Ponde, R. Goswami, D. Skovraonsky, S. Deng, J. Markamnn, and M. Kilborn. "F-18 (+) FP-DTBZ: a PET ligand for imaging VMAT2 binding sites in the brain and pancreas." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 234. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2007.
16. Kung, Mei-Ping, Brian Lieberman, Catherine Hou, Datta Ponde, Rajesh Goswami, Daniel Skovronsky, Shaoping Deng, James Markmann, and Hank Kung. "F-18 (+) FP-DTBZ: An investigational PET ligand for measuring beta cell mass in the pancreas Journal of Nuclear Medicine May 2007, 48 (supplement 2)114P.
17. Lakshmi, Balagopal, Mei-Ping Kung, Brian Lieberman, Jun Han, Rikki Waterhouse, and Hank Kung. "(R)-N-methyl-3-(3-125I-pyridin-2-yloxy)-3-phenylpropylamine: An improved SPECT ligand for norepinephrine transporters." Journal of Nuclear Medicine May 2007, 48 (supplement 2) 133P.
18. Manchanda, R., G. M. Golding, W. Zhang, T. E. Benedum, N. C. Lim, S. R. Choi, H. F. Kung et al. "Radiofluorinated alkynes as PET agents for the detection of amyloid plaques." In EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 34, pp. S398-S398. 233 SPRING STREET, NEW YORK, NY 10013 USA: SPRINGER, 2007.
19. Oya, Shunichi, Ajit Parhi, Julie Wang, Seok-Rye Choi, and Hank Kung. "Novel 4'-fluoroethyl-biphenylsulfides: Highly selective serotonin transporter imaging agents." Journal of Nuclear Medicine May 2007, 48 (supplement 2) 133P.
20. Qu, Wenchao, Mei-Ping Kung, Catherine Hou, Tyler Benedum, Rajesh Manchandra, Daniel Skovronsky, and Hank Kung. "Novel iodinated styrylpyridines for SPECT imaging of β-amyloid plaques." Journal of Nuclear Medicine May 2007, 48 (supplement 2) 303P
21. Qu, Wenchao, Mei-Ping Kung, Catherine Hou, and Hank Kung. "Radioiodinated alkynes as potential SPECT imaging agents for Alzheimer’s disease." Journal of Nuclear Medicine May 2007, 48 (supplement 2) 302P.
22. Qu, Wenchao, Mei-Ping Kung, Catherine Hou, and Hank Kung. "Bisphenyltriazoles as potential imaging agents for Alzheimer’s disease." Journal of Nuclear Medicine May 2007, 48 (supplement 2) 129P.
23. Rowe, Christopher C., Steven Ng, Rachel S. Mulligan, Uwe Ackermann, William Browne, Graeme O'Keefe, Henri J. Tochon-Danguy et al. "O1–04–02: Initial results from human studies of a novel F‐18 PET ligand for brain beta‐amyloid imaging." Alzheimer's & Dementia 3, no. 3S_Part_3 (2007): S173-S174.
24. Serdons, Kim, Michel Koole, Patrick Dupont, Peter Vermaelen, Rik Vandenberghe, Mathieu Vandenbulcke, Hank Kung, Guy Bormans, Alfons Verbruggen, and Koen Van Laere. "Preclinical evaluation and human dosimetry of the new F-18-labelled amyloid imaging agent KS28." European journal of nuclear medicine and molecular imaging 34 (2007): S138.
25. Tu, Zhude, Jinbin Xu, Shihong Li, Lynne Jones, Delphine Chen, Catherine Hou, Mei-Ping Kung et al. "Dual isotope study of a novel σ2 receptor ligand for PET and SPECT imaging studies of solid tumors." Journal of Nuclear Medicine May 2007, 48 (supplement 2) 18P.
26. Wei, Zhang, Kung Meip, Shunichi Oya, Catherine Hou, and Hank F. Kung. "{sup 18} F-labeled styrylpyridines as PET agents for amyloid plaque imaging." Nuclear Medicine and Biology 34 (2007).
2006
1. Chandra R, Kung MP, Kung HF. Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. doi: 10.1016/j.bmcl.2005.11.055. Epub 2005 Dec 1. PMID: 16325402.
2. Goswami R, Ponde DE, Kung MP, Hou C, Kilbourn MR, Kung HF. Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters. Nucl Med Biol. 2006 Aug;33(6):685-94. doi: 10.1016/j.nucmedbio.2006.05.006. PMID: 16934687.
3. Hou C, Tu Z, Mach R, Kung HF, Kung MP. Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker. Nucl Med Biol. 2006 Feb;33(2):203-9. doi: 10.1016/j.nucmedbio.2005.10.001. PMID: 16546674.
4. Newberg AB, Wintering NA, Plössl K, Hochold J, Stabin MG, Watson M, Skovronsky D, Clark CM, Kung MP, Kung HF. Safety, biodistribution, and dosimetry of 123I-IMPY: a novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease. J Nucl Med. 2006 May;47(5):748-54. PMID: 16644743.
5. Ono M, Kawashima H, Nonaka A, Kawai T, Haratake M, Mori H, Kung MP, Kung HF, Saji H, Nakayama M. Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. J Med Chem. 2006 May 4;49(9):2725-30. doi: 10.1021/jm051176k. PMID: 16640332.
6. Zhuang ZP, Kung MP, Kung HF. Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. doi: 10.1021/jm051020k. PMID: 16640346; PMCID: PMC2597440.
7. Lakshmi, Balagopal, Seok-Rye Choi, Rajesh Chandra, Zhi-Ping Zhuang, and Hank F. Kung. "MEDI 487-Binding selectivity of substituted diarylmethanes to serotonin transporters (SERT)." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 232. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2006.
8. Chandra, Rajesh, Karin Stephenson, Mei-Ping Kung, Catherine Hou, and Hank F. Kung. "MEDI 504-Synthesis of fluoro-PEGylated thiophene derivatives for beta-amyloid plaque imaging." In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol. 232. 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC, 2006.
9. Clark, Christopher M., Andrew B. Newberg, Marianne Watson, Nancy A. Wintering, Daniel M. Skovronsky, and Hank F. Kung. "P2–343: Imaging amyloid with I123 IMPY SPECT." Alzheimer's & Dementia 2 (2006): S342-S342.
10. Chandra, Raj, Karin Stephenson, Mei-Ping Kung, Catherine Hou, and Hank Kung. "2-Arylbenzothiazole derivatives for beta-amyloid plaque imaging." (2006): 217P-217P.
11. Song, Pujiao, Bernard Serge, Pierre Sarradin, Mei-ping Kung, Hank Kung, Jackie Vergote, and Denis Guilloteau. "IMPY, a beta-amyloid imaging probe for prion detection." (2006): 134P-134P.
12. Zhang, Wei, Mei-Ping Kung, Shunichi Oya, Catherine Hou, and Hank Kung. "F-18 labeled PEG stilbene derivatives as PET imaging agents for Alzheimer’s disease." Journal of Nuclear Medicine May 2006, 47 (suppl 1) 218P.
13. Oya, Shunichi, Seok Rye Choi, and Hank Kung. "Novel thiophenethiophenyl derivatives as serotonin transporter imaging agents." Journal of Nuclear Medicine May 2006, 47 (suppl 1) 497P.
14. Kung, Hank, Mei-Ping Kung, Rajesh Goswami, Datta Ponde, Catherine Hou, and Michael Kilbourn. "F-18 Fluoroalkyl dihydrotetrabenazine for imaging vesicular monoamine transporter 2 in the brain." Journal of Nuclear Medicine May 2006, 47 (suppl 1) 26P.
15. Serdons, Kim, Christelle Terwinghe, Peter Vermaelen, Hank Kung, Guy Bormans, and Alfons Verbruggen. "6-Methoxy-2-(4′-[18F] fluorophenyl)-1, 3-benzothiazole and 6-methyl-2-(4′-[18F] fluorophenyl)-1, 3-benzothiazole as potential amyloid imaging agents." Journal of Nuclear Medicine May 2006, 47 (suppl 1) 31P.
16. Newberg, Andrew, Nancy Wintering, Christopher Clark, Karl Ploessl, Daniel Skovronsky, John Seibyl, Mei-Ping Kung, and Hank Kung. "Use of 123I IMPY SPECT to differentiate Alzheimer’s disease from controls." Journal of Nuclear Medicine May 2006, 47 (suppl 1) 78P.
17. Stephenson, Karin, Hank Kung, Mei-Ping Kung, and Catherine Hou. "Styrylbenzoxazole derivatives for beta-amyloid plaque imaging." Journal of Nuclear Medicine May 2006, 47 (suppl 1) 497P.
18. Kung, H. F., and M. P. Kung. "PET and SPECT imaging agents for beta-amyloid plaques in the brain." In NEUROBIOLOGY OF AGING, vol. 27, pp. S12-S12. 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA: ELSEVIER SCIENCE INC, 2006.
19. Han, Jun, Erwen Mei, Mei-Ping Kung, Hank Kung, and Hai-Lung Dai. "Detection of β-Amyloid Peptide Dimer in Solution by Fluorescence Resonance Energy Transfer." In APS March Meeting Abstracts, pp. D13-003. 2006.
20. Hou, Catherine, M. P. Kung, D. Ponde, R. Goswami, M. Kilbourn, and H. Kung. "Imaging vesicular monoamine transporter sites with fluoroalkyl derivatives of dihydrotetrabenazine." Neuroimage 31 (2006): T14-T14.
21. Kung, Mei-Ping, W. Zhang, S. Oya, C. Hou, and H. Kung. "F-18 labeled PET agents for amyloid plaque imaging." NeuroImage 31 (2006): T51.
2005
1. Andrews, Christine M., Hank F. Kung, and Irwin Lucki. "The 5-HT1A receptor modulates the effects of cocaine on extracellular serotonin and dopamine levels in the nucleus accumbens." European journal of pharmacology 508, no. 1-3 (2005): 123-130.
2. Choi SR, Zhuang ZP, Chacko AM, Acton PD, Tjuvajev-Gelovani J, Doubrovin M, Chu DC, Kung HF. SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1). Acad Radiol. 2005 Jul;12(7):798-805. doi: 10.1016/j.acra.2005.04.010. PMID: 16039533.
3. Klunk B, Price J, Mathis C, Reiman E, Jack C, Fagan T, Kinoshita J, Albensi B, Tuller B, Kung HF, Andrews J. Alzheimer research forum live discussion: Imaging in Alzheimer's disease: The current state of affairs. Journal of Alzheimer's Disease. 2005;8(4):387-92.
4. Kung MP, Kung HF. Mass effect of injected dose in small rodent imaging by SPECT and PET. Nucl Med Biol. 2005 Oct;32(7):673-8. doi: 10.1016/j.nucmedbio.2005.04.002. PMID: 16243641.
5. Li, Zijun, Hui Qiao, Corinna Lebherz, Seok Rye Choi, Xiangyang Zhou, Guanping Gao, Hank F. Kung et al. "Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer." Human gene therapy 16, no. 12 (2005): 1429-1438.
6. Ono M, Haratake M, Nakayama M, Kaneko Y, Kawabata K, Mori H, Kung MP, Kung HF. Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease. Nucl Med Biol. 2005 May;32(4):329-35. doi: 10.1016/j.nucmedbio.2005.01.006. PMID: 15878502.
7. Zhang W, Oya S, Kung MP, Hou C, Maier DL, Kung HF. F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain. J Med Chem. 2005 Sep 22;48(19):5980-8. doi: 10.1021/jm050166g. PMID: 16162001; PMCID: PMC2593886.
8. Zhang W, Oya S, Kung MP, Hou C, Maier DL, Kung HF. F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Abeta aggregates in the brain. Nucl Med Biol. 2005 Nov;32(8):799-809. doi: 10.1016/j.nucmedbio.2005.06.001. PMID: 16253804.
9. Zhou, Rong, Daniel H. Thomas, Hui Qiao, Harshali S. Bal, Seok-Rye Choi, Abass Alavi, Victor A. Ferrari, Hank F. Kung, and Paul D. Acton. "In vivo detection of stem cells grafted in infarcted rat myocardium." Journal of Nuclear Medicine 46, no. 5 (2005): 816-822.
10. Zhuang ZP, Kung MP, Hou C, Ploessl K, Kung HF. Biphenyls labeled with technetium 99m for imaging beta-amyloid plaques in the brain. Nucl Med Biol. 2005 Feb;32(2):171-84. doi: 10.1016/j.nucmedbio.2004.10.002. PMID: 15721763.
11. Zhang, W., M-P. Kung, S. Oya, C. Hou, and H. F. Kung. "F-18-LABELED PEG STILBENE DERIVATIVES AS PET IMAGING AGENTS FOR beta-AMYLOID PLAQUES IN THE BRAIN." In JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 48, pp. S40-S40. COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA: WILEY-BLACKWELL, 2005.
12. Chandra, R., M-P. Kung, and H. F. Kung. "SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIP OF 2, 5-DISUBSTITUTED THIOPHENE DERIVATIVES FOR beta-AMYLOID PLAQUE IMAGING." In JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 48, pp. S167-S167. THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND: JOHN WILEY & SONS LTD, 2005.
13. Chacko, A-M., S-R. Choi, Z-P. Zhuang, and H. F. Kung. "5'-Amino nucleosides as markers for HSV1-tk gene expression." In JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 48, pp. S327-S327. THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND: JOHN WILEY & SONS LTD, 2005.
14. Kung, H. F., M-P. Kung, C. Hou, and Z-P. Zhuang. "Tc-99m-LABELED STILBENES AS POTENTIAL IMAGING AGENTS FOR beta-AMYLOID PLAQUES IN THE BRAIN." In JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 48, pp. S251-S251. COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA: WILEY-BLACKWELL, 2005.
15. Han, G., H. F. Kung, S. R. Choi, S. Makonnen, and W. Lee. "NOVEL SOMATOSTATIN PEPTIDOMIMETICS AS SOMATOSTATIN RECEPTOR SUBTYPE-2 SPECIFIC IMAGING AGENTS." In JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 48, pp. S265-S265. THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND: JOHN WILEY & SONS LTD, 2005.
16. Chen, X. J., B. L. Liu, and H. F. Kung. "QSAR STUDY OF STB SERIES OF IMAGING AGENTS FOR beta-AMYLOID PLAQUE." In JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 48, pp. S325-S325. THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND: JOHN WILEY & SONS LTD, 2005.
17. Kung, M. P., C. Hou, Z. P. Zhuang, D. Skovronsky, and H. F. Kung. "Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease (vol 1025, pg 98, 2004)." BRAIN RESEARCH 1031, no. 2 (2005): 302.
