HANK & LIN'S GROUP

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[18F]-D6-FP-DTBZ (P17-059，D6-AV133): A new VMAT2 imaging agent for PD (IND # 138682)

[18F]-D6-FP-DTBZ (D6-AV133): A new VMAT2 imaging agent for PD，https://mp.weixin.qq.com/s/Hk9QA8fMfaalmQBAc_5kaA

[18F]-D6-FP-DTBZ (D6-AV133): A new VMAT2 imaging agent for PD，https://mp.weixin.qq.com/s/Hk9QA8fMfaalmQBAc_5kaA

[18F]FP-DTBZ (AV133) VS [18F]-D6-FP-DTBZ (D6-AV133)

[18F]FP-DTBZ (AV133) VS [18F]-D6-FP-DTBZ (D6-AV133)

广医一院核医学科视频号（转载）

🌻VMAT2靶向显像剂[18F]D6-FP-DTBZ Vs [18F]AV-133 Publications:

  1. Liu, F., et al. "Deuterated 18F-9-O-hexadeutero-3-fluoropropoxyl-(+)-dihydrotetrabenazine (D6-FP-(+)-DTBZ): A vesicular monoamine transporter 2 (VMAT2) imaging agent." Nuclear medicine and biology 57 (2018): 42-49.
  2. Zhao, R., et al. "VMAT2 imaging agent, D6-[18F] FP-(+)-DTBZ: Improved radiosynthesis, purification by solid-phase extraction and characterization." Nuclear medicine and biology 72 (2019): 26-35.
  3. Sun, M., et al. "Rapid screening of nine unradiolabeled candidate compounds as PET brain imaging agents using cassette-wave microdosing and LC-MS/MS." Journal of Chromatography B 1121 (2019): 28-38.
  4. Ploessl, K., et al. "x Deuterium substituted D6FPDTBZ (P17-059) as a new VMAT2 imaging agent." Journal of Nuclear Medicine 59.supplement 1 (2018): 1030-1030.
  5. Kilbourn, M. "PET Imaging of Vesicular Monoamine Transporters." PET and SPECT of Neurobiological Systems. Springer, Cham, 2021. 1091-1132.
  6. Zhu, L., et al. "An improved radiosynthesis of [18F] AV-133: a PET imaging agent for vesicular monoamine transporter 2." Nuclear medicine and biology 37.2 (2010): 133-141.
  7. Xiao, H., et al. "Developing a cassette microdosing approach to enhance the throughput of PET imaging agent screening." Journal of pharmaceutical and biomedical analysis 154 (2018): 48-56.
  8. Zhu, L., et al. "A comparative dynamic PET imaging of monkey brains between solid phase extraction and HPLC purified 18F AV-133." Journal of Nuclear Medicine 51.supplement 2 (2010): 584-584.
  9. Zhu, L., et al. "Imaging of VMAT2 binding sites in the brain by 18F-AV-133: The effect of a pseudo-carrier." Nuclear medicine and biology 39.7 (2012): 897-904.
  10. Ruiyue Zhao, Zhihao Zha, Karl Ploessl, Seok Choi, Futao Liu, Lin Zhu and Hank Kung. Improved preparation of D6-[18F]FP-(+)-DTBZ: A new vesicular monoamine transporter 2 (VMAT2) imaging agent.Journal of Nuclear Medicine May 2019, 60 (supplement 1) 1617

  11. Zhao R, Zhang Y, Xu S, Alexoff D, Ploessl K, Chen L, Kung HF, Zhu L, Wang X. First-in-human study of D6-[18F] FP-(+)-DTBZ, a novel VMAT2 tracer: whole-body biodistribution and brain PET comparison with [18F] FP-(+)-DTBZ (AV-133). Journal of Nuclear Medicine. June 2024,65(supplement 2)241196

  12. Zhao, R., Chen, J., Ye, T.et al.First-in-human study of D6-[18F]FP-(+)-DTBZ, a novel VMAT2 tracer: whole-body biodistribution and brain PET comparison with [18F]FP-(+)-DTBZ (AV-133).EJNMMI radiopharm. chem.9, 71 (2024). https://doi.org/10.1186/s41181-024-00301-y

    Zhao, R., Chen, J., Ye, T.et al.First-in-human study of D6-[18F]FP-(+)-DTBZ, a novel VMAT2 tracer: whole-body biodistribution and brain PET comparison with [18F]FP-(+)-DTBZ (AV-133).


    EJNMMI radiopharm. chem.9, 71 (2024). https://doi.org/10.1186/s41181-024-00301-y

    18F-D6-FP-DTBZ (D6-AV133) PET imaging for PD （图片来自广州医科大学附属第一医院核医学科）
    VMAT2显像剂：美国FDA批准临床研究（I-II期）

    VMAT2显像剂：美国FDA批准临床研究（I-II期）

    Journal of Nuclear Medicine. June 2024,65(supplement 2)241196

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