HANK & LIN'S GROUP
The past is prologue and the future is scintillating
Publication (2020~2023)
2023
1.Wang, G., Li, L., Wang, J., Zang, J., Chen, J., Xiao, Y., Fan, X., Zhu, L., Kung, H.F. and Zhu, Z., 2023. Head-to-head comparison of [68Ga] Ga-P16-093 and 2-[18F] FDG PET/CT in patients with clear cell renal cell carcinoma: a pilot study. European Journal of Nuclear Medicine and Molecular Imaging, pp.1-11.
2.Bahler, C.D., Green, M.A., Tann, M.A., Swensson, J.K., Collins, K., Alexoff, D., Kung, H., Brocken, E., Mathias, C.J., Cheng, L. and Hutchins, G.D., 2023, January. Assessing extra-prostatic extension for surgical guidance in prostate cancer: Comparing two PSMA-PET tracers with the standard-of-care. InUrologic Oncology: Seminars and Original Investigations(Vol. 41, No. 1, pp. 48-e1). Elsevier.
3.Haiyan Hong, Zhihao Zha, Ruiyue Zhao, Yang Luo, Wenbin Jin, Linlin Li, Ran Wang, Li Yan, Hui Wang, Karl Ploessl, Jinping Qiao, Lin Zhu,and Hank F. Kung. [68Ga]Ga-HBED-CC-FAPI Derivatives with Improved Radiolabeling and Specific Tumor Uptake. Molecular Pharmaceuticals, 20(4), 2159-2169
4.Wang, Guochang, Linlin Li, Jie Zang, Haiyan Hong, Lin Zhu, Hank F. Kung, and Zhaohui Zhu. "Head-to-Head Comparison of68Ga-P16-093 and68Ga-PSMA-617 PET/CT in Patients With Primary Prostate Cancer: A Pilot Study."Clinical Nuclear Medicine(2023);48: 289–295.
5.Wang, Guochang, Linlin Li, Ming Zhu, Jiarou Wang, Rongxi Wang, Weigang Yan, Lin Zhu, Hank F Kung, Zhaohui Zhu. "A prospective head‑to‑head comparison of [68Ga]Ga‑P16‑093 and [68Ga]Ga‑PSMA‑11 PET/CT in patients with primary prostate cancer". European Journal of Nuclear Medicine and Molecular Imaging.
50, 3126–3136 (2023)
6.Zhihao Zha, Karl Ploessl, Seok Rye Choi, Ruiyue Zhao, Wenbin Jin, Ran Wang, David Alexoff, Lin Zhu and Hank F. Kung. "Lu-177-Labeled Hetero-Bivalent Agents Targeting PSMA and Bone Metastases for Radionuclide Therapy".J Med Chem. 2023:66 (17), 12602-12613
2022
1.Bahler, Clinton, Mark Green, Mark Tann, Katrina Collins, Jordan Swensson, Eric Brocken, Liang Cheng et al. "PD27-01 PREDICTING EXTRA-PROSTATIC EXTENSION (EPE) FOR SURGICAL GUIDANCE IN PROSTATE CANCER: A COMPARISON OF BIOPSY PATHOLOGY, MULTIPARAMETRIC MRI, AND PSMA-PET." The Journal of Urology 207, no. Supplement 5 (2022): e493.
2.Hong, Haiyan, Guochang Wang, Karl Ploessl, Zhihao Zha, Jie Zang, Zhaohui Zhu, Lin Zhu, and Hank F. Kung. "Kit-based preparation of [68Ga] Ga-P16-093 (PSMA-093) using different commercial 68Ge/68Ga generators." Nuclear Medicine and Biology 106 (2022): 1-9.
3.Lee, Hwan, Joshua S. Scheuermann, Anthony J. Young, Robert K. Doot, Margaret E. Daube-Witherspoon, Erin K. Schubert, Matthew A. Fillare et al. "Preliminary Evaluation of 68Ga-P16-093, a PET Radiotracer Targeting Prostate-Specific Membrane Antigen in Prostate Cancer." Molecular Imaging and Biology (2022): 1-11.
4.Wang, Guochang, Haiyan Hong, Jie Zang, Qingxing Liu, Yuanyuan Jiang, Xinrong Fan, Zhaohui Zhu, Lin Zhu, and Hank F. Kung. "Head-to-head comparison of [68 Ga] Ga-P16-093 and [68 Ga] Ga-PSMA-617 in dynamic PET/CT evaluation of the same group of recurrent prostate cancer patients." European journal of nuclear medicine and molecular imaging 49, no. 3 (2022): 1052-1062.
5.Zha, Z., S. R. Choi, L. Li, R. Zhao, K. Ploessl, X. Yao, D. Alexoff, L. Zhu, and H. F. Kung. "New PSMA-Targeting Ligands: Transformation from Diagnosis (Ga-68) to Radionuclide Therapy (Lu-177)." Journal of Medicinal Chemistry (2022)
6.Zhang, Yan, Guangwen Li, Yuli Sun, Haiyan Hong, Linlin Li, Yang Luo, Ran Wang, Lin Zhu, Hank F. Kung, and Jinxia Zhu. "In vivo and in vitro binding of [125 I] IR-(+)-TISCH: A dopamine D1 receptor ligand for studying pancreatic β-cell mass."Journal of labelled compounds & radiopharmaceuticals65, no. 14 (2022): 354-360.
2021
1. Guo, Rui, Xiangxi Meng, Fei Wang, Jiangyuan Yu, Qing Xie, Wei Zhao, Lin Zhu, Hank F. Kung, Zhi Yang, and Nan Li. "68Ga-P15-041, A Novel Bone Imaging Agent for Diagnosis of Bone Metastases." Frontiers in Oncology 11 (2021):766851.
2. Hong, Haiyan, Karl Ploessl, Zhihao Zha, Hui Wang, Rui Guo, Qing Xie, Hua Zhu, Zhi Yang, Lin Zhu, and Hank F. Kung. "Development and validation of a kit formulation of [68Ga] Ga-P15-041 as a bone imaging agent." Applied Radiation and Isotopes 169 (2021): 109485.
3. Li, Linlin, Ruiyue Zhao, Haiyan Hong, Guangwen Li, Yan Zhang, Yang Luo, Zhihao Zha et al. "68Ga-labelled-exendin-4: New GLP1R targeting agents for imaging pancreatic β-cell and insulinoma." Nuclear medicine and biology 102 (2021): 87-96.
4. Xiao, Hao, Seok Rye Choi, Ruiyue Zhao, Karl Ploessl, David Alexoff, Lin Zhu, Zhihao Zha, and Hank F. Kung. "A new highly deuterated [18F] AV-45,[18F] D15FSP, for imaging β-Amyloid plaques in the brain." ACS Medicinal Chemistry Letters 12, no. 7 (2021): 1086-1092.
5. Xu X, Zhu H, Kung HF, Li N, Yang Z. Benign Adrenal Nodule Mimicking Lymphoma Differentially Diagnosed by 18F-FDG and 18F-FGln PET/CT. Clin Nucl Med. 2021 Jun 1;46(6):474-476.
6. Zha, Zhihao, Seok Rye Choi, Karl Ploessl, David Alexoff, Ruiyue Zhao, Lin Zhu, and Hank F. Kung. "Radiolabeling Optimization and Preclinical Evaluation of the New PSMA Imaging Agent [18F] AlF-P16-093." Bioconjugate Chemistry 32, no. 5 (2021): 1017-1026.
7. Zha, Zhihao, Karl Ploessl, Seok Rye Choi, David Alexoff, and Hank F. Kung. "Preclinical evaluation of [18F] D3FSP, deuterated AV-45, for imaging of β-amyloid in the brain." Nuclear Medicine and Biology 92 (2021): 97-106.
8. Zhang, Qihui, Xiaobin Zhao, Peng Lei, Hank F. Kung, Zhi Yang, Lin Zhu, Shujing Wang et al. "Evaluating [68Ga] Ga-p14-032 as a Novel PET Tracer for Diagnosis Cerebral Amyloid Angiopathy." Frontiers in neurology (2021): 1885.
9. Lee, H., M. Daube-Witherspoon, J. Scheuermann, A. Young, R. Doot, E. Schubert, D. Alexoff, H. Kung, and D. Pryma. "Diagnostic performance of Ga-68-P16-093 PSMA PET/CT compared to F-18-fluciclovine PET/CT and Tc-99m-MDP scintigraphy in prostate cancer: a pilot study." In EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 48, no. SUPPL 1, pp. S447-S448. ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES: SPRINGER, 2021.
10. Li, Linlin, Ruiyue Zhao, Haiyan Hong, Yan Zhang, Zhihao Zha, Lin Zhu, and Hank Kung. "[68Ga] Ga-HBED-CC-exendin-4: A new GLP1R targeting radiolabeled agent for pancreas β-cell and insulinoma imaging." Nuclear Medicine and Biology 96 (2021): S47-S48.
11. Wang, Guochang, Jie Zang, Haiyan Hong, Qingxing Liu, Yuanyuan Jiang, Zhaohui Zhu, Lin Zhu, and Hank Kung. "A pilot prospective comparison of [68Ga] Ga-P16-093 and [68Ga] Ga-PSMA-617 in the same group of prostate cancer patients." (2021): 1329.
12. Zhang, Qihui, Xiaobin Zhao, Hank F. Kung, Zhi Yang, Lin Zhu, Peng Lei, Shujing Wang et al. "Abstract P339: Evaluating Ga68 Regional Distribution as a New Pet Tracerfor Diagnosis Cerebral Amyloid Angiopathy." Stroke 52, no. Suppl_1 (2021): AP339-AP339.
2020
1. Bahler, Clinton, Mark Tann, Mark Green, Gary Hutchins, Carla Mathias, Rumeal Barthel, H. (2020). Switching on Brain PET to Light Up Amyloid Pathology In Vivo (perspective on “In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18F-AV-45 (Florbetapir F 18)” J Nucl Med. 2010; 51: 913–920). Journal of Nuclear Medicine, 61(Supplement 2), 227S-235S.
2. Doot, Robert K., Anthony J. Young, Margaret E. Daube-Witherspoon, David Alexoff, Kyle J. Labban, Hwan Lee, Zehui Wu et al. "Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [68Ga] Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies." Nuclear medicine and biology 86 (2020): 1-8.
3. Gee, Antony D., Jan Andersson, Rajiv Bhalla, Yearn Seong Choe, David W. Dick, Matthias M. Herth, Eric D. Hostetler et al. "Training the next generation of radiopharmaceutical scientists." Nuclear Medicine and Biology 88 (2020): 10-13.
4. Green, Mark A., Gary D. Hutchins, Clinton D. Bahler, Mark Tann, Carla J. Mathias, Wendy Territo, Justin Sims et al. "[68Ga] Ga-P16-093 as a PSMA-targeted PET radiopharmaceutical for detection of cancer: initial evaluation and comparison with [68Ga] Ga-PSMA-11 in prostate cancer patients presenting with biochemical recurrence." Molecular imaging and biology 22, no. 3 (2020): 752-763.
5. Liu, Song, Renbo Wu, Yuli Sun, Karl Ploessl, Yan Zhang, Yajing Liu, Zehui Wu, Lin Zhu, and Hank F. Kung. "Design, synthesis and evaluation of a novel glutamine derivative (2 S, 4 R)-2-amino-4-cyano-4-[18 F] fluorobutanoic acid." New Journal of Chemistry 44, no. 21 (2020): 9109-9117.
6. Shi, Shengyu, Lifang Zhang, Zehui Wu, Aili Zhang, Haiyan Hong, Seok Rye Choi, Lin Zhu, and Hank F. Kung. "[68Ga] Ga-HBED-CC-DiAsp: A new renal function imaging agent." Nuclear Medicine and Biology 82 (2020): 17-24.
7. Xu, Xiaoxia, Hua Zhu, Fei Liu, Yan Zhang, Jianhua Yang, Lifang Zhang, Qing Xie et al. "Dynamic PET/CT imaging of 18F-(2S, 4R) 4-fluoroglutamine in healthy volunteers and oncological patients." European Journal of Nuclear Medicine and Molecular Imaging 47, no. 10 (2020): 2280-2292.
8. Yao, Xinyue, Zhihao Zha, Karl Ploessl, Seok Rye Choi, Ruiyue Zhao, David Alexoff, Lin Zhu, and Hank F. Kung. "Synthesis and evaluation of novel radioiodinated PSMA targeting ligands for potential radiotherapy of prostate cancer." Bioorganic & Medicinal Chemistry 28, no. 5 (2020): 115319.
9. Zha, Zhihao, Zehui Wu, Seok Rye Choi, Karl Ploessl, Megan Smith, David Alexoff, Lin Zhu, and Hank F. Kung. "A New [68Ga] Ga-HBED-CC-Bisphosphonate as a Bone Imaging Agent." Molecular Pharmaceutics 17, no. 5 (2020): 1674-1684.
10. Zhang, Lifang, Aili Zhang, Xinyue Yao, Yan Zhang, Futao Liu, Haiyan Hong, Zhihao Zha et al. "An improved preparation of [18F] AV‐45 by simplified solid‐phase extraction purification." Journal of Labelled Compounds and Radiopharmaceuticals 63, no. 3 (2020): 108-118.
11. Zhao, Ruiyue, Karl Ploessl, Zhihao Zha, Seokrye Choi, David Alexoff, Lin Zhu, and Hank F. Kung. "Synthesis and Evaluation of 68Ga-and 177Lu-Labeled (R)-vs (S)-DOTAGA Prostate-Specific Membrane Antigen-Targeting Derivatives." Molecular Pharmaceutics 17, no. 12 (2020): 4589-4602.
12. Green, Mark, Clint Bahler, Mark Tann, Gary Hutchins, Carla Mathias, Wendy Territo, Rumeal Whaley et al. "PSMA-targeted PET with [68Ga] Ga-P16-093: Initial evaluation in intermediate-risk and high-risk prostate cancer patients prior to prostatectomy." Journal of Nuclear Medicine May 2020, 61 (supplement 1) 192.
13. Whaley, Liang Cheng, David Alexoff, and Hank Kung. "PSMA-targeted PET with [68Ga] Ga-P16-093: Assessment of potential role in surgical planning for patients with intermediate-risk and high-risk prostate cancer." Journal of Nuclear Medicine May 2020, 61 (supplement 1) 1252.
14. Xu, Xiaoxia, Zhi Yang, and Hank Kung. "18F-FGln PET/CT guided surgical biopsy and resection in patient with brain tumors." Journal of Nuclear Medicine May 2020, 61 (supplement 1) 410.
